Cisplatin hplc
WebMar 1, 2024 · Cisplatin is a platinum containing compound used for the treatment of different types of cancers. Quantitative determination of cisplatin has been carried out using atomic absorption spectroscopy, high pressure liquid chromatography with phosphorescence, ultra-violet detection, or with inductively coupled plasma mass … WebCAS NO. 15663-27-1 Cisplatin was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death). Availability: In stock
Cisplatin hplc
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WebCisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Synonym (s): Cisplatin, CPDC, DDP, cis-Diaminedichloroplatinum Linear Formula: Pt (NH3)2Cl2 CAS Number: 15663-27-1 MDL number: MFCD00011623 NACRES: NA.77 WebJul 13, 2015 · Cisplatin is one of the first-choice drugs for the treatment of many cancers but it is not without its disadvantages, principally toxicity to the liver, kidney, brain and gastrointestinal tract, the initiation of hearing loss, and suppression of bone marrow.
WebCisplatin was the first of the platinum-based chemotherapeutic agents and therefore has been extensively studied as an antitumor agent since the late 1960s. Because this agent forms several DNA adducts, a highly sensitive and specific quantitative assay is needed to correlate the molecular dose of individual adducts with the effects of treatment. WebCisplatin, cis-diamminedichlorido-platinum(II), is an important therapeutic tool in the struggle against different tumors, yet it is plagued with the emergence of resistance mechanisms after repeated
WebSep 15, 2024 · Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL multiple dose … WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes …
Webcisplatin-plus lipoic acid (50 and 100 mg/kg)-treated rats, renal GSH-peroxidase activity significantly increased as compared to cisplatin alone (P ,0.01 and P 0.01) (fig. 3). The renal GSH-peroxidase activity in lipoic acid (100 mg/ kg) alone treated group was 247.02”15.52 mmoles NADPH oxidized/min./mg protein which was close to control value.
WebAug 15, 2007 · Paclitaxel and platinum analogs (cisplatin and carboplatin) is one such FDA approved combination administered sequentially for the treatment of different types of cancers; for example carboplatin in combination with paclitaxel is an approved therapy in patients with non small cell lung cancer (NSCLC), advanced and recurrent cervical … curtiss army fighters pdfWebcisplatin and with [Pt(en)Cl2]. 5 16 The reaction between 6 (cis isomer purified as a mixture of two diastereomers) and the oligonucleotide (1:1) was carried out in H 2O at 37ºC (Scheme 3). As shown by HPLC, three new broad peaks with higher retention time than the parent oligonucleotide were slowly 10 generated (20% after 24 h). curtiss at-9 fledglingWebFeb 28, 2024 · Gold nanoparticles enhance cisplatin delivery and potentiate chemotherapy by decompressing colorectal cancer vessels. Xiaoxu Zhao 1 Department of General Surgery, ... HPLC analysis detected high concentrations of cisplatin in tumors after combined therapy, both of which indicated that the delivery efficacy of cisplatin was … chase bank western ave chicagoWebAug 19, 2005 · Cisplatin is a widely used anti-tumor agent for the treatment of testicular and ovarian cancers. Carboplatin is used extensively for small cell, non small cell lung cancer … curtiss army hawks pdfWebNov 1, 2008 · We found that AGT is readily cross-linked to DNA in the presence of cisplatin. HPLC-ESI⁺-MS/MS sequencing of tryptic peptides originating from dG-Pt-AGT complexes revealed that the cross-linking ... curtiss andersonWebFeb 26, 2015 · Cisplatin and apigenin were purchased from Sigma-Aldrich (St. Louis, MO, USA). All other reagents were of analytical grade or HPLC grade, and were obtained from DIMA Technology, Inc. (Richmond Hill, GA, USA). Analytical procedures. Cisplatin was separated by HPLC using a Symmetry C18 column (50×2.1 mm; Waters Corporation, … chase bank western avenue chicagoWebCisplatin is an anti-tumor agent widely employed in cancer chemotherapy. A specific and selective method for the quantitative determination of cisplatin in human plasma and its applications to pharmacokinetic … curtiss at-9 jeep